![]() By using Mediafly’s technology and advisory services, marketing and sales teams at companies including PepsiCo, Disney, GE Healthcare, Colgate-Palmolive and Charles Schwab, are able to deliver custom, dynamic sales presentations quickly and efficiently, engaging customers with insights that are relevant to them. Mediafly is a provider of sales enablement solutions and advisory services that create dynamic, interactive, value-based selling experiences. For more information about Mediafly’s Evolved Selling™ platform: About Mediafly This announcement follows the promotion of John Evarts as President and COO and the appointment of Andrew Miehl as Chief Customer Officer as the company experiences continued growth. “Not only do we get more out of our Mediafly app, our reps now enter their meetings with the confidence that comes from knowing their presentation stands out from the competition.” While we were already differentiating ourselves by using Mediafly’s value-selling calculators, Presentify took our original PowerPoint presentation and created a simpler, more visual message that our sales team is actually excited to use,” said Greg Bell, Head of Product Marketing at 6sense. “Buyers are bombarded with static, boring presentations. “After partnering with Mediafly on a range of projects, it became clear to me that adding Presentify to Mediafly’s suite of solutions provides both companies an opportunity to have a greater impact on customers around the world, helping them get even more out of their sales enablement technology investment to close deals faster and drive revenue.” “To truly enable marketing and sales teams, companies must have interactive, visually immersive content that makes their message capture buyer attention among the clutter,” said Nathan Jackson, founder and managing director of Presentify, incoming Mediafly EVP – Presentify. By combining the power of Presentify’s visual communications capabilities with its enterprise-grade technology, Mediafly becomes the only such multi-faceted sales enablement platform in the market. Marketing and sales teams can feel confident through Mediafly’s leading AI-powered content usage analytics to know exactly what’s working, what isn’t, and their content’s contribution to revenue. Mediafly users can now build selling stories using sophisticated visual communication capabilities all through the Mediafly app, which natively supports the most advanced content formats, animations and modularized assets for elevated sales storytelling. “With Presentify, Mediafly now tears down the barrier of entry for these companies, allowing them to quickly refresh their sales stories with interactive, animated content - and learn the ‘Presentification’ techniques to create and maintain sales collateral that is a league above their competition.” But all too often they don’t want to take their antiquated, boring sales content and put it into a sophisticated sales app for fear of garbage in, garbage out,” said Carson Conant, CEO and founder of Mediafly. “More companies are recognizing the need for digital sales transformation, and the importance of using a modern sales enablement platform. From sales presentations to a product marketing one-pager, the content experience must be thought-provoking, interactive and engaging. To get the most out of a sales enablement platform, sales and marketing teams must transform ordinary content that is static and boring to extraordinary stories that visually stand-out. While sales enablement technology is the proven medium for sellers to deliver their sales stories in a way that resonates with modern buyers, to maximize return on investment, sales organizations need inspiring content. These challenges are amplified in the COVID economy where sellers have to work smarter to capture remote buyers’ attention and keep it. Mediafly, a provider of sales enablement technology, content management and advisory services that create interactive, value-based selling experiences, announced today it has acquired Presentify, a global visual communication solution based in the UK.Īs B2B buyers have grown more sophisticated, selling has become more challenging. Expanding its global presence and adding customers like Barclaycard, Pitney Bowes and Avalara, the acquisition further enforces Mediafly’s commitment to placing content at the center of everything it does, helping customers create an optimal buyer engagement experience that accelerates the path to purchase and drives revenue. Sales enablement platform acquires global visual communication solution to help brands improve buyer engagement with interactive contentĬHICAGO - Mediafly, a provider of sales enablement technology, content management and advisory services that create interactive, value-based selling experiences, announced today it has acquired Presentify, a global visual communication solution based in the UK.
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![]() Thank you to Renorasims for getting us the resource needed to enable Studio for the Toddler Stuff Pack and testing to make sure it works. Thank you to simtress and Julie J for getting us the resource needed to enable Studio for the Fitness Stuff Pack and testing to make sure it works. Support for all DLC packs up to the Carnaval Streetwear Kit.Model viewer settings that allow you to change the background color and toggle the grid on and off. ![]() Drag & Drop Swatch Reordering - this feature works on the Studio tab and when using the My CC feature.Your batchfix backup folder is here: Documents/Sims 4 Studio/Batch Fixes This will reverse all changes that were made by the batch fix, returning your content to the way it was before you ran the batch fix. What should I do if one of the Studio batch fixers messed up my content? -> Copy the contents of your batchfix backup folder and paste it into your mods folder. What should I do if I fixed my messed up hairs by running a batch fixer that made them look right but stopped them from working with the color sliders? -> Run the Update Hairs for Color Slider Compatibility batch fixerģ. What should I do if my hairs were previously compatible with the color sliders and were messed up by the latest patch? -> Run the Update Slider Compatible Hair (Werewolf patch) batch fixĢ. This will convert your RLE2 images to LRLE images compatible with the color slider mod.ġ. *Please note: if you have previously run a batch-fix process using some other application that converted all your LRLEs back to RLE2s, then you will need to run the batch fix named Update Hairs for Color Slider Compatibility. Copy the contents of your batchfix backup folder and paste it into your mods folder. ![]() Send me the broken package, so I can see what went wrong and fix it.Ģ. If you discover something that was fixed incorrectly please do the following:ġ. We have tested them, but due to the great variety in Sims 4 custom content, there could still be issues we did not encounter in our tests. Disable Shoes for Werewolves - this updates shoe packages to use the new shoe settings that prevent werewolves from using them. Update Sliders (Werewolf patch) - this updates slider mods rendered non-functional in the latest patch.Ĥ. ![]() This will work on older hairs that weren't made compatible to begin with and on hairs that were previously run through another application's batch fix to turn broken LRLEs back into RLE2s (please see note(*) below).ģ. Update Hairs for Color Slider Compatibility - makes hairs that aren't compatible with the color slider mod color slider compatible. Update LRLE Images (Werewolf patch) - this fixes textures on any hair, skin detail, skin tone (or anything else affected by this image problem) you have that was broken with the recent patch.Ģ. There are four batch fixes in this update.ġ. There is also a batch fix for CC beds that broke with the High School Years patch and one to remove fashion tags from CAS items (currently these tags can cause error 532 when saving). Added support for all packs up to the High School EP and SDX content. ![]() Chase is hot on the trail, and he’s finally found out that Forrest Blackwell, the rich benefactor and businessman, has a sinister plot for the planet. Here, we’re focusing on the Secret Base level. This giant compound is action-packed - you’ll have to deal with super-strong spacesuit soldiers, laser cannons, and a new Astronaut Disguise upgrade. ![]() Don’t let the many puzzles hold you back, check out everything you need to know below.Chapter 3: Go Directly to Jail | Albatross Prison Island.Chapter 3: Go Directly to Jail | Bluebell Mine.Chapter 10: Back on the Case | Uptown Museum.Chapter 10: Back on the Case | LEGO City Fire Station.Chapter 11: The Proof of the Pudding | Blackwell’s Mansion: Robbery.Chapter 11: The Proof of the Pudding | Pappalardo’s Ice Cream Parlor.Chapter 13: Secrets | Blackwell’s Mansion: Investigation.The chapter begins right away! You’re thrust into the hidden base beneath the mountain. Level 13 begins too, so be prepared to fight your way through Rex Fury’s gang. You’re so close to the truth now – an unseen figure is discussing nefarious plans with Rex Fury, including the location for Dr. A gang of thugs appear at the loading area. When the goons are arrested, move to the right wall and repair the fuse box (Construction Disguise) to turn off the electricity. Smash the formerly-wired LEGO crate to find a smaller box. Build the hopping bricks when you place it – and hit the security switch. Use the computer inside the glass-encased room to open the main shutters to the massive ledge over a long, long drop. To go deeper into the secret base, go to the overhang through the newly-open door and begin the long drop. Destroy the blue LEGO dish on the helipad to creature a diving board.įollow the LEGO studs as you fall – there are huge circles that helpfully show Chase where to go. You’ll be able to avoid the platforms and walkways and other obstructions. Falling down the cliffs, keep moving to avoid the incoming laser blasts and avoid the spinning energy in the tunnel.Īt the bottom of the long drop, you’ll land in a submarine bay. To progress, you’ll need to enhance the large crane in the center of the dock. Start by smashing the large LEGO crate – build the hopping bricks to add extra parts to the crane. In the far-left corner of the room, use the Space Crate (Astronaut Disguise) to teleport a bundle of TNT. Grab it (Miner Disguise) and place it in the barrel near the shiny metal LEGO crate. Build those leftover hopping bricks to complete the crane – all you need to do is use the controls. ![]() ![]() The crane pulls an engine out of the sub. Repair the engine with the Construction Disguise to launch into the huge metal doors. They look dangerous, but they can be arrested like any other criminals! The blast completely destroys the gate, and red-clad spacemen jetpack into the area. Go through the destroyed door to ride the lift down into the massive underground chamber. Smash the white / gray LEGO box and construct the bricks inside to create a ladder up to the second floor.ĭefeat the waiting goons, then break open the door on the back wall (left of the laser grid) with the Robber Disguise. On the second floor, step onto the exterior walkway and cut through (Fireman Disguise) to reach the Color Swapper. Collect green from the Color Swapper and shoot the red light at the top of the previous ladder. That opens a door with a jetpack upgrade.The jetpack upgrade is exclusively added to the Astronaut Disguise.Now you can jump higher, and holding jump allows you to hover in the air. Find red Super Jetpack Markers and activate to create red stud circles – while hovering, you’ll recharge after flying through a circle. Return to the balcony and use the Super Jetpack marker to fly right and land on the lower walkway. Down here, follow the studs up and back – climb the crates and jetpack up to the catwalk with a ladder. Climb the ladder, then glide into the foreground, then left to reach the third floor. Use the terminal on the test track to send the little cart into the laser grid. Build the hopping bricks to create a TNT vending machine. Grab the dynamite with the Miner Disguise, then fly back to the top of the ladder you used earlier – there’s a metal LEGO crate you can destroy. Set the TNT to cause all sorts of havoc in the base. ![]() ![]() A free trial is available to download from the Parallels website. Users who purchased a perpetual license for an earlier version of Parallels Desktop can upgrade to Parallels Desktop 17 for $49.99. Parallels Desktop 17 has moved entirely to a subscription model, which means the standard edition costs $79.99 per year, while Pro and Business Editions are available for $99.99 per year. Windows 10 will also recognize macOS battery status and turn on battery saving mode when your Mac runs low on battery. M1 users can also now use BitLocker and Secure Boot thanks to a virtualized TPM (Trusted Platform Module) chip. Coherence will now window shutdowns, updates, and sign-in screens, while drag-and-drop between Windows and Mac apps has been enhanced, with support for dragging text and images between windows, including support for Quick Notes in Monterey. If you're running it on an Apple silicon machine, expect 33% faster Windows startup times, up to 20% better disk performance on Windows 10 Insider Preview, and up to 28% faster DirectX 11 performance.Įlsewhere, Parallels has improved its Coherence mode, which lets you run a windows app without launching the full virtual machine. With that caveat, for both M1 and Intel systems, Parallels 17 resumes Windows and Linux up to 38% faster compared to the previous version, and benefits from a sixfold increase in OpenGL graphics processing and up to a 25% improvement in 2D graphics performance, according to the company. However, Parallels has promised that when Windows 11 is officially released to the public, the virtualization software will be able to run it. It's worth noting from the off that the versions of Windows that Parallels 17 can run on an M1 Mac are currently limited to the Insider Previews for Windows 10 and Windows 11, due to their compatibility with ARM-based hardware. So, users can no longer be distracted from important tasks, since the shutdown and logon screens will now be displayed in a separate window that can be easily minimized.Parallels Desktop 17 was released today, bringing native support for Windows 11 and macOS Monterey to both Intel and Apple silicon Macs, as well as a range of performance and compatibility improvements. ![]() Supporto completo a Apple M1, Windows 11 e MacOS Monterey di Franco Aquini - 06:00 0 La nuova versione di Parallels Desktop 17 porta tante. It will allow you to run Windows and Mac applications at the same time without even opening a Windows virtual machine window. Parallels 17, la trasformazione è completa. The software comes with improvements made to the Coherence mode. It also provides higher frame rates in many 2D games such as Foregone and Smelter. The similar for graphics processing with DirectX 11, that is now 28% faster.Īdditionally, Parallels Desktop 17 introduces an improved display driver that improves the responsiveness and usability of the Windows user interface. Also, drive data transfer is now 20% faster. Macs with Apple M1 chips now run 33% faster on Windows 10 on ARM. In addition, on devices with Intel processors in macOS Big Sur virtual machines (or newer), the network connection speed is 60% faster than before. 2D graphics performance on Windows improved by 25%. Also, it renders OpenGL graphics six times faster. In terms of performance improvements, Parallels says Windows, Linux and macOS systems are now 38% faster to resume on all supported devices. The release of both systems is scheduled for the end of 2021, but now you can install preliminary versions of them in a virtual machine. The latter can act as both the main and guest operating systems. The main innovation in Parallels Desktop 17, of course, is support for Windows 11 and macOS Monterey. Our womens grooming kit includes a variety of specially sized trimmers and combs designed to remove hair from head to toe at a moment’s notice. Save your money and time and get literally anything else. Expertly trim and shape your eyebrows, face and bikini area with the Schick Hydro Silk perfect finish beauty tool. ![]() I also have the worst razor burn in my life from it currently. Save your $$ and buy something else.WASTE OF MONEY1I tried this one time and the razor head broke off completely mid swipe. Tried replacing the batteries and nothing. ![]() I exchanged it back the next morning for a new one.Stopped Working1Completely stopped working a week after I started using it. Old version was betterGreat until it dies completely2Was great and handy until it just stopped working after 3-4 months.The first one was used!2I bought one, brought it home and opened what I thought was a brand new razor/ trimmer… only to find HAIR in the trimmer part. The Schick Hydro Silk Razor offers a soft, rubber handle with grooved grips for optimal control, and is designed to keep the cartridge out of water when stored flat in the. I still have the old version of this product from over 3 years ago, which still works, so obviously Schick can do better than this.Good while it last1Trimmer stop working it just die completely. Schick Hydro Silk Trimstyle Bikini Razors for Women with Bikini Trimmer Womens Razors, 5 Blade Razors for Women, Bikini Hair Removal 1 Handle & 3 Razor Blade Refills. TrimStyle is a 2-in-1 tool with a razor on one end and pubic hair trimmer on the other. After that, it won't work without a new battery. The Schick Hydro Silk TrimStyle razor and waterproof bikini trimmer provides more personalized shaving. Now it's exhibiting the same problem as the first razor: With a new battery, the trimmer works for a single use from the time I turn it on to the time I turn it off - even if that was only a few seconds. I exchanged it for a new one, figuring the first was just defective, and the second one fared a lot better. The razor is a much better shave and the trim side is super easy to use for those certain areas! I also love how when you set it down the razor doesn't touch the bathtub and sticks to it.Broke twice :(I bought one of these a few months ago, and after a few uses it seemingly consumed an entire battery charge in a single (5 minute) use of the trimmer. It is bigger and a bit more bulkier but I don't mind it. Schick razors for women and womens trimmers help you achieve your shaving goals. The Schick ® Quattro ® Titanium Trimmer is a 3 in 1 convenient shaving tool to shave, edge and trim your facial hair. Love it!I switched from Venus embrace and instantly noticed a difference. Enjoy Free Shipping Hydro Silk 5 TrimStyle Razor 14. ![]() I know, I know… I do love chocolate so much, especially my dark chocolate cake. You’re probably thinking, “What? Courtney doesn’t want chocolate to take over? I’m so confused!” When I started to create this cake in my mind, I knew that I didn’t want to use my chocolate cake as the base because I didn’t want chocolate to overpower the cake. I’m not sure why it’s taken me so long to create this one, but it’s finally here! Reese’s Take 5 Cake This is a flavor combination my little brother, and several of you, have requested for some time now. Have you ever had a Reese’s Take 5 candy bar? It’s all of my favorite things in one candy bar: chocolate, peanut butter, caramel, pretzel! Amazing, right? Gently dip each pretzel into the chocolate to cover.With pretzel cake layers, peanut butter filling, chocolate covered pretzel crunch filling, salted caramel and chocolate buttercream, this Reese’s Take 5 Cake is the epitome of sweet and salty perfection! Reese’s Take 5.Healthier Copycat Reese’s Eggs (vegan + gluten-free)ĥ-ingredient Copycat Peanut Butter M&Ms (gluten-free) For all of my favorite healthy candy recipes head on over to this blog post! Healthier Copycat Butterfingers (gluten-free) Add each chocolate pretzel to baking sheet and set in freezer until chocolate is hardened and enjoy!Ī few other popular homemade candy recipes on the blog:.I put a pretzel on a fork and use a spoon to drizzle chocolate over it Gently dip each pretzel into the chocolate to cover.Add to freezer to set for 10 minutes and begin melting the chocolate in the microwave or over stove.Remove caramel and pretzels from fridge and add a teaspoon of caramel on top one each pretzel then add a few crushed peanuts to each.Add a teaspoon or so of peanut butter on top of each pretzel then another pretzel then add to fridge to set for 10 minutes.While the caramel thickens, line a baking sheet with parchment paper and add half of the pretzels across.Remove from heat and add to a small container to put in fridge to thicken for about 10 minutes.Turn the heat to medium/low and cook for about 10 minutes, stirring every couple minutes.Add in the coconut milk and vanilla extract and mix.In a small saucepan, combine the water and coconut sugar and bring to a low boil How to make copycat Take 5 Candy Bars and homemade caramel: Full-fat coconut milk – the top cream part! Please don’t use another milk as it will be too liquid.Coconut sugar – I haven’t tested another sugar here.1 cup dark chocolate – code RACHL for free shipping on my go-to chocolate. ![]() Crushed peanuts – I used roasted and unsalted.Creamy peanut butter code RACHL for free shipping on my favorite peanut butter.Gluten-free pretzel twists – I also have used the gluten-free ones from Trader Joe’s! Any pretzels you love works.What ingredients you need for gluten-free Take 5 Candy Bars and a vegan homemade caramel: I hope you guys love them as much as I do! You will also see a handful of other candy recipes liked below to whip up this Halloween season (or any season of the year in my opinion). Even Ezra’s nanny couldn’t get over how flipping good they are! These Take 5’s have a permanent spot in my freezer and I grab one throughout the day to snack on right now. Don’t let the homemade caramel sauce fool you – it takes minimal effort to whip up and tastes so perfect in this recipe. This recipe is surprisingly very easy to make. These homemade Take 5 Candy Bars though – hot damn! You guys are in for a really good salty, sweet and crunchy snack that can also live your freezer. I was the girl literally counting each Reese’s Peanut Butter Cup she got on Halloween and putting them in the freezer to snack on all year around. But when it comes to really anything Reese’s makes – I am always satisfied. How did I live under a rock when it came to how dreamy Reese’s Take 5 Candy Bars are?! These were most definitely not a thing when I was trick or treating or going crazy at the candy aisle growing up. A healthier copycat Reese’s Take 5 candy bar recipe with pretzels, peanut butter, homemade vegan caramel, peanuts and coated in dark chocolate. Mini Gluten-free Take 5 Candy Bars made with all vegan ingredients. ![]() Shut down any lingering program versions or PDF-displaying browsers.Here's the lowdown on installing the PDF reader from Internet Explorer, Firefox, and Google Chrome: How to install Adobe Reader on your PCįor those rocking Microsoft Windows 7 or newer, snagging Adobe Acrobat Reader DC is a piece of cake, no matter your browser of choice. ![]() You can create passwords or enable the mode of access by means of a certified ID.Īs for the Adobe Document Cloud services, yes, they are secure. This can be done in Adobe Acrobat, whose security settings allow you to define who will be able to read, open, print, copy or modify each document. However, Adobe Acrobat Reader DC does not allow you to set up security or access privileges for the files. It also blocks access to confidential data, as well as its extraction, whether from the computer itself or from the corporate network to which it was connected. This prevents third parties from installing malicious software. This PDF reader has a protected mode, which is nothing more than sandbox technology enabled by default. The ‘protected mode’ of Adobe Acrobat Reader DC for Windows A trial version is available for download. Storage in the premium version increases to 20GB. The option of combining several PDF documents into a single file is also associated with the paid subscription. It allows you to change the order of pages to improve reading and to transform PDFs into editable Word, PowerPoint, RTF or Excel files. The most important functions of the Adobe Acrobat Reader DC are those related to editing PDF files. Premium features of subscriptions to this PDF reader The desktop software for Windows incorporates the fill in and sign tool, making it easy to fill in PDF forms. Now you can also register with Adobe Document Cloud that allows you to: file storage (also offers 2 GB of free storage), immediate access to recent files from any mobile and desktop device, synchronization of the filling and signing tool to complete forms in any device, and real-time sending and tracking of files, including notification when the document is opened, shared or downloaded. One of the features incorporated in the latest updates is Adobe Scan that allows you to transform documents into high-quality PDF files and incorporates text recognition functionality. It is a program that allows you to view files from any mobile device with Android or iOS without any problem. This makes it easy for the user to work with PDF documents on any device and from any location.Īlthough the software is free, it also has a paid-for premium version that works by subscription. In addition, the Adobe Acrobat Reader DC is connected to Adobe Document Cloud services. This includes multimedia content and forms. In fact, as the manufacturer claims, it’s the only PDF reader that can open and interact with all types of content in this format. ![]() You can share your documents in PDF using Dropbox, WeTransfer or whatever platform that you like. ![]() Its functions of this tool are to view PDF documents, print PDFs, sign documents with e-signature, comment on PDF files and share the content with other devices. Adobe claims that its Adobe Acrobat Reader DC is not just a PDF reader, but the free global standard by which all products of this type are measured. ![]() “Obviously, a crazy comeback,” Forsberg said. Konecny scored on a breakaway at 5:03 followed by Filppula’s power-play goal for a 5-3 lead that seemed safe until Forsberg pulled Nashville within a goal 50 seconds later to set up the amazing finish. Philadelphia took advantage of its third power play in the period when Filppula scored on a wrister at 15:05, tying it at 3. McDonald scored his first goal on a slap shot at 10:19, and Patrick, the second overall pick in the June draft, got his first career goal 16 seconds later on a wrister. ![]() Then the Flyers turned the celebration into a game. Mattias Ekholm skated across the crease, and his backhand shot went off Elliott to Bonino, who easily tapped the puck in for a 3-0 lead and his first goal since leaving Pittsburgh for Nashville this offseason. Hartnell beat Elliott with a slap shot off the rebound of teammate Pontus Aberg’s shot at 3:08 for a 2-0 lead. Nashville scored first in the second period, too. That gave Nashville its first lead this season, and the Predators took eight of the first 10 shots. Nashville Predators Logo PNG Vector Nashville Predators logo png icon vector. 35 was retired by the team in 2022 and was hoisted to Bridgestone Arena’s rafters along with the franchise’s other banners. ![]() Browse Getty Images premium collection of high-quality, authentic Nashville Tennessee Banner stock photos, royalty-free images, and pictures. Then the Predators gave their fans reason to keep cheering, with Smith scoring a power-play goal with a wrister past Brian Elliott at 4:17 of the first period. Browse 427 nashville tennessee banner photos and images available, or start a new search to explore more photos and images. (Image credit: Alexander Zemlianichenko Jr./Bloomberg via Getty Images) Russian president Vladimir Putin at the 2011 opening of the Nord Stream 1 pipeline, in which Gazprom is a major partner. VKPlay is run by VKontakte, a social media company often referred to as 'Russia's Facebook' over which Gazprom has effective control via investments made by subsidiaries and affiliate companies. Gazprom is Russia's state-run energy giant which generates scads of cash for the government, has been instrumental in the ongoing economic warfare between Russia and the west, and which was reported to be creating its own private military company as recently as last week.Ītomic Heart is also being distributed via VKPlay in Russia-after sanctions led Steam to effectively end business there-and a few other countries. Here's what's definitely true: GEM Capital founder Anatoliy Paliy worked as first deputy general director for a Gazprom subsidiary-Gazprom Gazenergoset-in the past, before going into business for himself alongside other Gazprom management types in the 2010s. But the other two quickly became more controversial in the wake of the invasion, with audiences placing both companies under the microscope to figure out where they stood in relation to the war, and whether they might be financially supporting the Russian state. Tencent is, well, Tencent, the Chinese tech behemoth that owns whole segments of the gaming industry, from a piece of Epic Games, Discord, and Ubisoft to Riot Games in its entirety. In early 2021, over a year before Russian tanks rolled into Ukraine, Mundfish announced that it had secured funding from three key investors: Tencent, GEM Capital, and Gaijin Entertainment (the maker of War Thunder). (Image credit: Mundfish) Following the money: Mundfish's investors I've reached out to the studio to ask about its statement on the war, and I'll update this section if I hear back. ![]() It could be that Mundfish's tweet was an ungraceful attempt to thread a political needle without jeopardising itself, its staff, or those associated with either. Marking oneself as anti-war in that kind of environment is an act of profound courage and incredible risk. The Russian political scientist and anti-war activist Greg Yudin described this system as one that generates "incredible contempt and disdain for all kinds of politics" among Russians, who are "completely certain that there is no possible way to change anything through politics, that no change is possible in general". ![]() The Russian state has taken a hard line against any and all internal protest against its so-called " special military operation" in Ukraine, arresting thousands of protestors, threatening years in prison camps over anti-war social media posts, and charging a political opposition figure with treason for "spreading disinformation" about the Russian army.Įven when Russia isn't at war, the country maintains a deeply alienating political system that has entrenched power among a cabal of lackeys and oligarchs for decades. ![]() On the other hand, whether it's headquartered in Cyprus or not, Mundfish is a studio with Russian roots and Russian staff (with Russian family and Russian friends), as a 2019 article documenting a tour of its Moscow office will attest. A video from a Ukrainian YouTuber titled " Please, Don't Buy Atomic Heart"-which has managed to accrue nearly 2 million views in just over a week-highlighted the absurdity of a game based around an alt-history USSR claiming it doesn't "comment on politics," calling it "absolute nonsense" and "one step away from the types of gamers who say 'I don't like politics in my videogames' and then immediately open up Fallout". ![]() Mundfish's statements that it was only interested in "getting Atomic Heart into the hands of gamers everywhere," or that it was " For players who just want to play," struck some people as, at best, a marketing attempt to redirect the conversation surrounding its game or, at worst, some kind of tacit support for the actions of its original home country. "We're for all the good things and against all the bad ones" Sergey Mohov mocks Mundfish's statement Mundfish's reticence to even name the war in question sparked outrage, summed up by tweets from game designer Sergey Mohov, who mocked Mundfish's position as "We're for all the good things and against all the bad ones," lambasting the studio for "having the unbelievable privilege to have this kind of position". It was not the statement of support for Ukrainian independence that some were hoping for. ![]() ![]() Although some studies have shown that endotoxin measurements may be of value in predicting outcome and presence of gram-negative bacteremia, other studies have been inconclusive, and the clinical value of endotoxin measurement in patients with sepsis remains unclear. A large number of previous studies have attempted to measure endotoxin in the circulation of patients with sepsis and relate these findings to other clinical, microbiologic, and pathophysiologic findings. ![]() Although this detection system is highly sensitive, it is susceptible to a number of interfering substances found in human plasma, which may activate or inhibit the Limulus reaction independent of endotoxin itself. Endotoxin levels are often measured by using a Limulus amebocyte lysate reactivity assay. The measurement of endotoxin in the systemic circulation has been complicated by the fact that humans are exquisitely susceptible to endotoxin, and accurate measurement of endotoxin in plasma is technically difficult. Injection of larger doses of endotoxin (∼1 mg) into humans has been followed by severe hypotension and multiorgan dysfunction within 2 h of intravenous administration. Īdministration of endotoxin to humans in minute quantities (2–4 ng/kg) precipitates typical signs and symptoms of clinical sepsis, activates the complement and coagulation systems, and triggers release of the proinflammatory cytokines. These host-derived mediators function in concert to induce the systemic inflammatory response syndrome. These effector cells appear to be activated through a family of Toll-like receptors and subsequently release a network of proinflammatory mediators, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-8, IL-12, cyclic endoperoxides, platelet-activating factor, complement tissue factor, and other inflammatory products. This complex macromolecule induces its injurious effects by a noncytotoxic interaction with CD14-bearing inflammatory cells, which include the macrophage-monocyte lineage and circulating neutrophils. The quantitative level of both endotoxin and LBP may have prognostic significance in patients with severe sepsis.īacterial endotoxin, a component of the outer cell membrane of gram-negative bacteria, is a principal mediator in the pathophysiology of gram-negative bacterial sepsis. No correlation was found between endotoxin and LBP levels. 05) in nonsurvivors than survivors over the 28-day study period. ![]() 01), and LBP levels were less highly elevated (28.0 vs. Median endotoxin levels at study entry were more highly elevated (515 vs. Median LBP levels in patients with sepsis were 31.2 µg/mL (interquartile range, 22.5–47.7 µg/mL). LBP levels were elevated in 97% of patients compared with normal control values of 4.1 ± 1.65 µg/mL. Median endotoxin levels in patients with sepsis were 300 pg/mL (25%–75% interquartile range, 110–726 pg/mL). Endotoxin levels were significantly greater than control levels ( n = 33 mean ± SD, 5.1 ± 7.3, pg/mL) in 78.3% of patients. Plasma endotoxin and lipopolysaccharide-binding protein (LBP) levels were measured in a group of 253 patients at the onset of severe sepsis and/or septic shock. |
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